Place two racks in center of oven and preheat to 475°F. Line two baking sheets with parchment paper and set aside.
In a saucepan, combine hot sauce, brown sugar, apple cider vinegar, salt, and red pepper flake over medium-high heat. Bring to a boil, then reduce heat to a simmer and let cook 8-10 minutes. Remove from heat.
In a large bowl, combine chicken, garlic, salt, pepper, eggs, panko, paprika, and onion powder. Mix ingredients together well but do not over mix.
Roll mixture into balls about 3 tablespoons in size. Place meatballs on prepared baking sheet and bake until cooked through, 11-13 minutes.
Once cooked, dip each meatball into the sauce. Return back to baking sheet and bake 2 minutes more. Drizzle with additional sauce if desired.